Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | RORA | P35398 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | RORB | Q92753 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963546 | 0.91 | PGR (0.59) | TOP2AHDAC1ALDH1A1KDM4EPGR | |
| SCHEMBL6295469 | 0.85 | MAPK8 (0.57) | MAPK8ALDH1A1KDM4EPGRKMT2A | |
| SCHEMBL12933336 | 0.85 | TOP2A (0.51) | TOP2AHDAC1ALDH1A1KDM4EPGR | |
| SCHEMBL6362477 | 0.84 | PGR (0.68) | MAPK8HDAC1ALDH1A1KDM4EPGR | |
| SCHEMBL30485670 | 0.84 | PGR (0.68) | MAPK8HDAC1ALDH1A1KDM4EPGR | |
| SCHEMBL25936308 | 0.83 | TOP2A (0.58) | TOP2AHDAC1ALDH1A1KDM4EPGR | |
| SCHEMBL6295236 | 0.82 | MAPK8 (0.55) | MAPK8ALDH1A1KDM4EPGRKMT2A | |
| SCHEMBL12963428 | 0.81 | PGR (0.61) | MAPK8ALDH1A1KDM4EPGRKMT2A | |
| SCHEMBL22201345 | 0.80 | PGR (0.72) | MAPK8TOP2AHDAC1PGRKMT2A | |
| SCHEMBL17241700 | 0.79 | HDAC1 (0.60) | HDAC1ALDH1A1KMT2AHTR6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |