⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435609 | 0.78 | — | — | |
| SCHEMBL24400455 | 0.76 | BRD4 (0.36) | — | |
| SCHEMBL198982 | 0.74 | — | — | |
| SCHEMBL9809155 | 0.74 | L3MBTL1 (0.42) | — | |
| SCHEMBL28360493 | 0.72 | BRD4 (0.42) | — | |
| SCHEMBL18019315 | 0.67 | — | — | |
| SCHEMBL10767319 | 0.67 | — | — | |
| Succinchlorimide SCHEMBL72 | 0.67 | — | — | |
| SCHEMBL2455005 | 0.67 | — | — | |
| Succinchlorimide SCHEMBL1465495 | 0.67 | BRD4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022628-B1 | PROCESS FOR THE PREPARATION OF OXAZOLINOAZETIDINONES | ELI LILLY AND COMPANY (US) | 1983-06-22 | — | — | EP | claimed |
| EP-0022628-A1 | Process for the preparation of oxazolinoazetidinones | ELI LILLY AND COMPANY (US) | 1981-01-21 | — | — | EP | claimed |
| US-4243588-A | CYCLIZING A 2-CHLOROAZETIDINONE WITH LEAD FLUORIDE IN DIMETHYL SULFOXIDE TO OBTAIN THE 4-OXA-2,6-DIAZABICYCLO(3.2.0)HEPTANE | ELI LILLY AND COMPANY (US) | 1981-01-06 | — | — | US | claimed |
| US-5892036-A | Process for the preparation of 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines | PLIVA FARMACEUTSKA (HR) | 1999-04-06 | — | — | US | disclosed |
| US-5847119-A | 2-bromo-and derivatives of 3-bromo-and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and use thereof | PLIVA, FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, DIONICKO DRUSTVO (HR) | 1998-12-08 | — | — | US | disclosed |
| EP-0633247-B1 | 2-Bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and use thereof | PLIVA PHARM & CHEM WORKS (HR) | 1998-05-27 | — | — | EP | disclosed |
| US-5670638-A | 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, and preparation | PLIVA FARMACEUTSKA (HR) | 1997-09-23 | — | — | US | disclosed |
| US-5637581-A | Preparations containing 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines | PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, DIONICKO DRUSTVO ZAGREB (HR) | 1997-06-10 | — | — | US | disclosed |
| EP-0633247-A1 | 2-Bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and use thereof | PLIVA FARMACEUTSKA KEMIJSKA PREHRAMBENA I KOZMETICKA INDUSTRIJA DIONICKO DRUSTVO ZAGREB (HR) | 1995-01-11 | — | — | EP | disclosed |
| EP-0132394-B1 | IMPROVEMENTS IN OR RELATING TO THE PREPARATION OF 3-EXOMETHYLENE CEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1988-10-12 | — | — | EP | disclosed |
| US-4772692-A | AZETIDINONES | HOECHST UK LIMITED (GB) | 1988-09-20 | — | — | US | disclosed |
| EP-0022628-A1 | Process for the preparation of oxazolinoazetidinones | ELI LILLY AND COMPANY (US) | 1981-01-21 | — | — | EP | disclosed |
| US-4243587-A | CYCLIZING A 3-ACYLAMINO-4A-ACETOXYAZETIDINONE ESTER WITH HYDROCHLORIC ACID TO OBTAIN THE 4-OXA-2,6-DIAZABICYCLO(3.2.0)HEPTANE | ELI LILLY AND COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4243588-A | CYCLIZING A 2-CHLOROAZETIDINONE WITH LEAD FLUORIDE IN DIMETHYL SULFOXIDE TO OBTAIN THE 4-OXA-2,6-DIAZABICYCLO(3.2.0)HEPTANE | ELI LILLY AND COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4226767-A | NOCARDICIN | ELI LILLY AND COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| US-4206120-A | Oxaazabicycloheptane antibiotics | BEECHAM GROUP LIMITED (GB) | 1980-06-03 | — | — | US | disclosed |
| US-4195021-A | 1,3-Disubstituted 2-azetidinone antibitotics | ELI LILLY AND COMPANY (US) | 1980-03-25 | — | — | US | disclosed |
| US-4180507-A | NOCARDICIN INTERMEDIATE | ELI LILLY AND COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| EP-0001715-A2 | Azetidinone antibiotics and their pharmaceutical formulations and use | ELI LILLY AND COMPANY (US) | 1979-05-02 | — | — | EP | disclosed |
| US-4127568-A | Process for 3β-aminoazetidin-2-ones | ELI LILLY AND COMPANY (US) | 1978-11-28 | — | — | US | disclosed |