Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.51 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.51 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954484 | 0.96 | TGFBR1 (0.50) | TGFBR1ACVRL1ACVR1BMEN1ALDH1A1 | |
| SCHEMBL5955511 | 0.87 | TGFBR1 (0.54) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL8348081 | 0.86 | TGFBR1 (0.58) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL5954832 | 0.86 | TGFBR1 (0.58) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL8347338 | 0.86 | TGFBR1 (0.59) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL5954828 | 0.86 | TGFBR1 (0.60) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL5954715 | 0.86 | TGFBR1 (0.58) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL8346119 | 0.86 | TGFBR1 (0.57) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL3826786 | 0.85 | TGFBR1 (0.56) | TGFBR1ACVRL1ACVR1BBUB1 | |
| SCHEMBL14223120 | 0.85 | TGFBR1 (0.56) | TGFBR1ACVRL1ACVR1BBUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |