Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.70 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225267 | 1.00 | CTSK (0.70) | CTSKCTSSCCR1ITGB3ITGA2B | |
| SCHEMBL4225270 | 1.00 | CTSK (0.70) | CTSKCTSSCCR1ITGB3ITGA2B | |
| SCHEMBL4225274 | 1.00 | CTSK (0.70) | CTSKCTSSCCR1ITGB3ITGA2B | |
| SCHEMBL5941332 | 0.94 | CTSK (0.76) | CTSKCTSSCCR1ALDH1A1HPGD | |
| SCHEMBL4218525 | 0.94 | CTSK (0.76) | CTSKCTSSCCR1ALDH1A1HPGD | |
| SCHEMBL4218529 | 0.94 | CTSK (0.76) | CTSKCTSSCCR1ALDH1A1HPGD | |
| SCHEMBL4218526 | 0.94 | CTSK (0.76) | CTSKCTSSCCR1ALDH1A1HPGD | |
| SCHEMBL4040961 | 0.93 | CTSK (0.73) | CTSKCTSSCCR1ALDH1A1HPGD | |
| SCHEMBL4217872 | 0.92 | CTSK (0.72) | CTSKCTSSCCR1ALDH1A1HPGD | |
| SCHEMBL4217876 | 0.92 | CTSK (0.72) | CTSKCTSSCCR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |