Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.78 |
| ▸ | MMP10 | P09238 | 2/20 | 0.62 |
| ▸ | MMP8 | P22894 | 2/20 | 0.62 |
| ▸ | MMP9 | P14780 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349714 | 0.89 | MMP13 (0.61) | MMP13MMP10MMP8MMP9ADORA2A | |
| SCHEMBL8358823 | 0.89 | MMP13 (1.00) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL29838134 | 0.89 | MMP13 (1.00) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL12272887 | 0.85 | MMP13 (0.92) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL8357428 | 0.84 | MMP13 (0.90) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL4716566 | 0.84 | MMP13 (0.90) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL14284143 | 0.84 | MMP13 (0.90) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL8349710 | 0.84 | MMP13 (0.77) | MMP13MMP10MMP8MMP9HPGD | |
| SCHEMBL8360162 | 0.83 | MMP13 (0.88) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL8350613 | 0.83 | MMP13 (0.88) | MMP13MMP10MMP8MMP9HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060883-A1 | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |