SCHEMBL8348482

SCHEMBL8348482

Nc1ccccc1NC(=O)/C=C/c1ccc(Br)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.68
TRPM8 Q7Z2W7 1/20 0.68
HDAC1 Q13547 12/20 0.63
EGFR P00533 2/20 0.60
HDAC2 Q92769 3/20 0.59
HDAC4 P56524 2/20 0.58
HDAC3 O15379 1/20 0.58
HDAC7 Q8WUI4 1/20 0.58
HDAC10 Q969S8 1/20 0.58
HDAC11 Q96DB2 1/20 0.58
HDAC8 Q9BY41 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
HDAC9 Q9UKV0 1/20 0.58
HDAC5 Q9UQL6 1/20 0.58
MEF2D Q14814 1/20 0.57
MMP1 P03956 3/20 0.56
MMP2 P08253 3/20 0.56
MMP9 P14780 3/20 0.56
CHEK1 O14757 1/20 0.55
PIM1 P11309 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4536420 1.00 TRPA1 (0.68) TRPA1TRPM8HDAC1EGFRHDAC2
SCHEMBL4536422 1.00 TRPA1 (0.68) TRPA1TRPM8HDAC1EGFRHDAC2
SCHEMBL2640602 0.88 HDAC1 (0.66) HDAC1EGFRHDAC2MMP1MMP2
SCHEMBL3228583 0.88 EGFR (0.71) HDAC1EGFRHDAC2HDAC4HDAC3
SCHEMBL3228591 0.88 EGFR (0.71) HDAC1EGFRHDAC2HDAC4HDAC3
SCHEMBL8349389 0.87 HDAC1 (0.83) HDAC1HDAC2HDAC4HDAC3HDAC7
SCHEMBL1064940 0.87 HDAC1 (0.83) HDAC1HDAC2HDAC4HDAC3HDAC7
SCHEMBL3565983 0.87 HDAC1 (0.83) HDAC1HDAC2HDAC4HDAC3HDAC7
SCHEMBL7978520 0.87 HDAC1 (0.64) HDAC1EGFRHDAC2MMP1MMP2
SCHEMBL13151248 0.86 HDAC1 (0.62) TRPA1TRPM8HDAC1HDAC2HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7868204-B2 Inhibitors of histone deacetylase METHYLGENE INC. (CA) 2011-01-11 US disclosed
US-7868204-B2 Inhibitors of histone deacetylase METHYLGENE INC. (CA) 2011-01-11 US disclosed
US-7838520-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2010-11-23 US disclosed
US-7838520-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2010-11-23 US disclosed
EP-1590340-B1 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE INC (CA) 2010-04-07 EP disclosed
US-7595343-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2009-09-29 US disclosed
US-7595343-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2009-09-29 US disclosed
WO-2004069823-A1 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2004-08-19 WO disclosed
WO-2003024448-A2 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2003-03-27 WO disclosed