Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 7/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348539 | 1.00 | LTB4R (0.41) | LTB4RALOX5PDE4BMEN1POLB | |
| SCHEMBL8352997 | 1.00 | LTB4R (0.41) | LTB4RALOX5PDE4BMEN1POLB | |
| SCHEMBL8348546 | 1.00 | LTB4R (0.41) | LTB4RALOX5PDE4BMEN1POLB | |
| SCHEMBL8353000 | 1.00 | LTB4R (0.41) | LTB4RALOX5PDE4BMEN1POLB | |
| SCHEMBL8348170 | 0.91 | LTB4R (0.47) | LTB4RALOX5 | |
| SCHEMBL8348174 | 0.91 | LTB4R (0.47) | LTB4RALOX5 | |
| SCHEMBL8348180 | 0.91 | LTB4R (0.47) | LTB4RALOX5 | |
| SCHEMBL8347631 | 0.91 | LTB4R (0.43) | LTB4RALOX5PDE4B | |
| SCHEMBL8347621 | 0.91 | LTB4R (0.43) | LTB4RALOX5PDE4B | |
| SCHEMBL8347615 | 0.91 | LTB4R (0.43) | LTB4RALOX5PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952326-A | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5698550-A | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1997-12-16 | — | — | US | disclosed |
| EP-0441515-B1 | Tetralin and chroman derivatives in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1991012253-A1 | TETRALIN AND CHROMAN DERIVATIVES USEFUL IN THE TREATMENT OF ASTHMA, ARTHRITIS, AND RELATED DISEASES | PFIZER INC. (US) | 1991-08-22 | — | — | WO | disclosed |