Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | APAF1 | O14727 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10055019 | 0.92 | MAPT (0.82) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL1844199 | 0.92 | MAPT (0.82) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL5669873 | 0.92 | MAPT (0.82) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL22783768 | 0.87 | MAPT (0.74) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL8060137 | 0.86 | MEN1 (0.80) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL8345852 | 0.85 | MAPT (0.72) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL169696 | 0.85 | MAPT (0.72) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL11935861 | 0.84 | MAPT (0.70) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL14809315 | 0.84 | MAPT (1.00) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL10924995 | 0.84 | RAB9A (0.70) | MAPTGAAL3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |