SCHEMBL8348773

SCHEMBL8348773

NC[C@]1(CC(=O)O)C[C@H]2CCCC[C@H]2C1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.55
ALDH1A1 P00352 2/20 0.55
USP2 O75604 1/20 0.55
LMNA P02545 1/20 0.55
TSHR P16473 1/20 0.55
BLM P54132 1/20 0.55
CACNA2D1 P54289 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
HSD11B1 P28845 1/20 0.34
CYP2D6 P10635 2/20 0.33
CYP3A4 P08684 1/20 0.33
POLB P06746 1/20 0.33
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14559606 1.00 CYP1A2 (0.55) CYP1A2ALDH1A1USP2LMNATSHR
SCHEMBL5384976 1.00 CYP1A2 (0.55) CYP1A2ALDH1A1USP2LMNATSHR
SCHEMBL14559584 1.00 CYP1A2 (0.55) CYP1A2ALDH1A1USP2LMNATSHR
SCHEMBL5390449 0.98 ALDH1A1 (0.58) CYP1A2ALDH1A1USP2LMNATSHR
Hydrochloric Acid SCHEMBL5384785 0.98 CYP1A2 (0.53) CYP1A2ALDH1A1USP2LMNATSHR
SCHEMBL14559594 0.96 CYP1A2 (0.55) CYP1A2ALDH1A1USP2LMNATSHR
SCHEMBL14559590 0.96 CYP1A2 (0.55) CYP1A2ALDH1A1USP2LMNATSHR
SCHEMBL5382165 0.96 CYP1A2 (0.55) CYP1A2ALDH1A1USP2LMNATSHR
Hydrochloric Acid SCHEMBL5381205 0.94 CYP1A2 (0.53) CYP1A2ALDH1A1USP2LMNATSHR
SCHEMBL7432467 0.93 CYP1A2 (0.53) CYP1A2ALDH1A1USP2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506955-B1 Bicyclic amino acids as pharmaceuticals agents WARNER LAMBERT CO (US) 2007-03-28 EP disclosed
US-7189747-B2 Method of treating noninflammatory cartilage damage WARNER-LAMBERT COMPANY (US) 2007-03-13 US disclosed
WO-2003063845-A1 ALPHA 2 DELTA LIGANDS TO TREAT TINNITUS WARNER-LAMBERT COMPANY LLC (US) 2003-08-07 WO disclosed