Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30591353 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2FKBP1AALDH1A1EPHX1HSD17B10 | |
| SCHEMBL8441504 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2FKBP1AALDH1A1EPHX1HSD17B10 | |
| SCHEMBL8349246 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2FKBP1AALDH1A1EPHX1HSD17B10 | |
| SCHEMBL23394661 | 0.91 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1HSD17B10ATMMEN1 | |
| SCHEMBL30557032 | 0.91 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1HSD17B10ATMMEN1 | |
| SCHEMBL30556981 | 0.91 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1HSD17B10ATMMEN1 | |
| SCHEMBL9437527 | 0.89 | ATM (0.40) | SMN1; SMN2FKBP1AALDH1A1EPHX1HSD17B10 | |
| SCHEMBL9437520 | 0.89 | ATM (0.40) | SMN1; SMN2FKBP1AALDH1A1EPHX1HSD17B10 | |
| SCHEMBL115093 | 0.87 | MEN1 (0.41) | FKBP1AALDH1A1HSD17B10ATMMEN1 | |
| SCHEMBL31109924 | 0.87 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1EPHX1HSD17B10NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872135-A | ENZYME INHIBITORS | MERK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| US-5869682-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5661161-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0783518-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5627202-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-06 | — | — | US | disclosed |
| WO-1996010035-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |