Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.70 |
| ▸ | CTSS | P25774 | 4/20 | 0.52 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.39 |
| ▸ | HTR3B | O95264 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 4/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.39 |
| ▸ | CTSV | O60911 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044153 | 1.00 | CTSK (0.70) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4043170 | 0.94 | CTSK (0.63) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4045504 | 0.93 | CTSK (0.61) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4046431 | 0.92 | CTSK (0.60) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4045527 | 0.92 | CTSK (0.60) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4039365 | 0.92 | CTSK (0.59) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4042100 | 0.92 | CTSK (0.59) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4042777 | 0.91 | CTSK (0.57) | CTSKCTSSHPGDSCTSBCHRNA7 | |
| SCHEMBL4043757 | 0.90 | CTSK (0.57) | CTSKCTSSHPGDSCCR1CTSB | |
| SCHEMBL4044858 | 0.90 | CTSK (0.57) | CTSKCTSSHPGDSCTSBCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |