Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | NAT1 | P18440 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4160642 | 0.86 | CYP19A1 (0.38) | CYP19A1CYP11B1CYP11B2MAOAMAOB | |
| SCHEMBL4160641 | 0.86 | CYP19A1 (0.38) | CYP19A1CYP11B1CYP11B2MAOAMAOB | |
| SCHEMBL13801990 | 0.84 | AKR1B1 (0.34) | CYP19A1MAOAMAOBPIM1PIM2 | |
| SCHEMBL4153586 | 0.83 | NR3C1 (0.49) | CYP19A1CYP11B1CYP11B2MAOAMAOB | |
| SCHEMBL4153587 | 0.83 | NR3C1 (0.49) | CYP19A1CYP11B1CYP11B2MAOAMAOB | |
| SCHEMBL4167521 | 0.81 | NR3C1 (0.61) | CYP19A1CYP11B1CYP11B2MAOAMAOB | |
| SCHEMBL4167518 | 0.81 | NR3C1 (0.61) | CYP19A1CYP11B1CYP11B2MAOAMAOB | |
| SCHEMBL13801992 | 0.79 | NR3C1 (0.60) | MAOAMAOBPIM1NR3C1PGR | |
| SCHEMBL4152786 | 0.74 | AR (0.43) | CYP19A1CYP11B1CYP11B2MAOAMAOB | |
| SCHEMBL4152784 | 0.74 | AR (0.43) | CYP19A1CYP11B1CYP11B2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052847-A2 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |