SCHEMBL8350252

SCHEMBL8350252

Cc1noc(NS(=O)(=O)c2ccccc2-c2cccnc2)c1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 14/20 1.00
EDNRB P24530 8/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7951160 0.94 EDNRA (1.00) EDNRAEDNRB
SCHEMBL6151288 0.88 EDNRA (1.00) EDNRAEDNRB
SCHEMBL8566691 0.85 EDNRA (1.00) EDNRAEDNRB
SCHEMBL8568947 0.84 EDNRA (1.00) EDNRAEDNRB
SCHEMBL6777867 0.83 EDNRA (0.86) EDNRAEDNRB
SCHEMBL7947185 0.82 EDNRA (1.00) EDNRAEDNRB
SCHEMBL8347975 0.82 EDNRA (1.00) EDNRAEDNRB
SCHEMBL7951249 0.81 EDNRA (1.00) EDNRAEDNRB
SCHEMBL6772118 0.81 EDNRA (0.76) EDNRAEDNRB
SCHEMBL7948221 0.81 EDNRA (1.00) EDNRAEDNRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5939446-A HYPOTENSIVE AGENTS FROM ISOXAZOLESULFONAMIDES BRISTOL-MYERS SQUIBB CO. (US) 1999-08-17 US claimed
US-5939446-A HYPOTENSIVE AGENTS FROM ISOXAZOLESULFONAMIDES BRISTOL-MYERS SQUIBB CO. (US) 1999-08-17 US disclosed