Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.67 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL834080 | 0.88 | PARP1 (0.65) | PARP1HTR2CHTR2AHTR2BTDP1 | |
| SCHEMBL833220 | 0.80 | PARP1 (1.00) | PARP1 | |
| SCHEMBL835994 | 0.76 | PARP1 (0.49) | PARP1HTR2CL3MBTL1HTR2AHTR2B | |
| SCHEMBL2022596 | 0.70 | PARP1 (0.59) | PARP1HTR2CHTR2AHTR2BDRD3 | |
| SCHEMBL834078 | 0.70 | PARP1 (0.63) | PARP1HTR2CHTR2AHTR2BTDP1 | |
| SCHEMBL834523 | 0.70 | PARP1 (0.61) | PARP1HTR2CL3MBTL1HTR2AHTR2B | |
| SCHEMBL835746 | 0.68 | PARP1 (1.00) | PARP1 | |
| SCHEMBL4714259 | 0.68 | BDKRB1 (0.60) | PARP1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2227448 | 0.67 | HRH3 (0.60) | PRMT6SMN1; SMN2TDP1ALDH1A1CYP2D6 | |
| SCHEMBL29678370 | 0.67 | HRH3 (0.60) | PRMT6SMN1; SMN2TDP1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| US-8362052-B2 | Isoindolin-1-one derivative | MSD K.K. (JP) | 2013-01-29 | — | — | US | disclosed |
| US-8143284-B2 | 2-cyclohexyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide; allergic encephalitis, arthritis, cardiac and kidney toxicities from doxorubicin-based and platinum-based antineoplastic agents, carcinoma of the breast, central nervous system inflammation, cervical carcinoma, | ABBOTT LABORATORIES (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | MSD K.K. (JP) | 2011-12-22 | — | — | US | disclosed |
| WO-2010104195-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |
| US-20080108659-A1 | POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ABBVIE INC. | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312976-A1 | NOVEL ISOINDOLIN-1-ONE DERIVATIVE | CBR3, OPRD1, CBR1 | PARP1 2962/4885HTR2C 778/4885MBTD1 845/4885 |
| US-20080108659-A1 | POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP11, PARP2 | PARP1 1/4885HTR2C 4265/4885MBTD1 4045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.