SCHEMBL8352192

SCHEMBL8352192

CC(C)(N)CC(C)(C)c1ccc(C(C)(C)CC(C)(C)N)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHBG P04278 1/20 0.50
TAAR1 Q96RJ0 2/20 0.42
CYP3A4 P08684 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
NPC1 O15118 1/20 0.38
MAPT P10636 1/20 0.38
RAB9A P51151 1/20 0.38
SLC6A2 P23975 2/20 0.37
HTR2A P28223 1/20 0.34
SLC6A4 P31645 1/20 0.34
HRH1 P35367 1/20 0.34
HTR2B P41595 1/20 0.34
CHRNA4 P43681 1/20 0.34
SLC6A3 Q01959 1/20 0.34
PDE2A O00408 1/20 0.34
TSHR P16473 2/20 0.33
TP53 P04637 1/20 0.33
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23221272 0.93 SHBG (0.45) SHBGTAAR1CYP3A4SMN1; SMN2NPC1
SCHEMBL14685623 0.91 TSHR (0.48) SHBGTAAR1CYP3A4SMN1; SMN2ESR1
SCHEMBL19026593 0.89 SHBG (0.69) SHBGCYP3A4SMN1; SMN2ESR1ESR2
SCHEMBL19033678 0.87 TAAR1 (0.60) SHBGTAAR1CYP3A4ESR1ESR2
SCHEMBL21862602 0.87 SHBG (0.41) SHBGTAAR1SMN1; SMN2ESR1ESR2
SCHEMBL14685562 0.85 CYP2D6 (0.40) SHBGTAAR1CYP3A4SMN1; SMN2NPC1
SCHEMBL22631906 0.85 SHBG (0.39) SHBGTAAR1CYP3A4SMN1; SMN2ESR1
SCHEMBL19285946 0.83 SHBG (0.34) SHBGTAAR1SLC6A2HTR2ASLC6A4
SCHEMBL22448856 0.83 SHBG (0.38) SHBGTAAR1CYP3A4SMN1; SMN2NPC1
SCHEMBL8352080 0.83 SHBG (0.38) SHBGTAAR1CYP3A4SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4205767-A1 DRUG-LOADED MACROMOLECULE AND PREPARATION METHOD THEREFOR Shanghai Senhui Medicine Co., Ltd. (CN) 2023-07-05 EP disclosed
EP-2052011-B1 TARGETED POLYLYSINE DENDRIMER THERAPEUTIC AGENT STARPHARMA PTY LTD (AU) 2020-11-04 EP disclosed
WO-2013018817-A1 NOVEL COMPOUND, POLYMER, CROSS-LINKED COMPOUND OF POLYMER, AND OPTICAL ELEMENT INCLUDING CROSS-LINKED COMPOUND CANON KABUSHIKI KAISHA (JP) 2013-02-07 WO disclosed
WO-2003068234-A1 NICOTINAMIDE DERIVATIVES AND A TIOTROPIUM SALT IN COMBINATION FOR THE TREATMENT OF E.G. INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES PFIZER LIMITED (GB) 2003-08-21 WO disclosed
WO-2003068232-A1 NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS PFIZER LIMITED (GB) 2003-08-21 WO disclosed