Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.51 |
| ▸ | EDNRB | P24530 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568610 | 0.96 | EDNRA (0.53) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL8697810 | 0.89 | EDNRA (0.45) | EDNRAEDNRBTP53MAPTALDH1A1 | |
| SCHEMBL8573715 | 0.88 | EDNRA (0.52) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL8572868 | 0.87 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL6640800 | 0.87 | EDNRB (0.41) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL8568832 | 0.85 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL8348111 | 0.85 | EDNRA (0.51) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL6778008 | 0.85 | EDNRB (0.40) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL6770266 | 0.85 | EDNRB (0.39) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL8348292 | 0.85 | EDNRA (0.48) | EDNRAEDNRBTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939446-A | HYPOTENSIVE AGENTS FROM ISOXAZOLESULFONAMIDES | BRISTOL-MYERS SQUIBB CO. (US) | 1999-08-17 | — | — | US | disclosed |