Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | MAOB | P27338 | 3/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.70 |
| ▸ | DPP4 | P27487 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639692 | 0.91 | DPP4 (0.72) | ALDH1A1NPSR1TSHRLMNAHTT | |
| SCHEMBL4667706 | 0.88 | DPP4 (0.73) | ALDH1A1NPSR1TSHRLMNAHTT | |
| SCHEMBL555311 | 0.87 | DPP4 (0.78) | ALDH1A1TSHRLMNAMAPTDPP4 | |
| SCHEMBL4668963 | 0.87 | DPP4 (0.78) | ALDH1A1TSHRLMNAMAPTDPP4 | |
| SCHEMBL8337418 | 0.87 | ALDH1A1 (0.74) | ALDH1A1NPSR1TSHRLMNAHTT | |
| SCHEMBL13939265 | 0.86 | DPP4 (0.81) | ALDH1A1NPSR1TSHRLMNAHTT | |
| SCHEMBL12604413 | 0.86 | DPP4 (0.81) | ALDH1A1NPSR1TSHRLMNAHTT | |
| SCHEMBL4668737 | 0.85 | DPP4 (0.71) | ALDH1A1NPSR1TSHRLMNAHTT | |
| SCHEMBL4076753 | 0.85 | DPP4 (0.71) | ALDH1A1NPSR1TSHRLMNAHTT | |
| SCHEMBL4668639 | 0.85 | DPP4 (0.71) | ALDH1A1NPSR1TSHRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057200-A2 | COMPOSITIONS COMPRISING INHIBITORS OF DPP-IV AND NEP ENZYMES FOR THE TREATMENT OF DIABETES | NOVO NORDISK A/S (DK) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003004496-A1 | DPP-IV-INHIBITING PURINE DERIVATIVES FOR THE TREATMENT OF DIABETES | NOVO NORDISK A/S (DK) | 2003-01-16 | — | — | WO | disclosed |