Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | F7 | P08709 | 4/20 | 0.42 |
| ▸ | F3 | P13726 | 4/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IARS1 | P41252 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6787476 | 0.86 | F3 (0.44) | F2F10F7F3PLG | |
| SCHEMBL6348347 | 0.77 | F2 (0.55) | KDM4EF2F10F7F3 | |
| SCHEMBL7652022 | 0.75 | F3 (0.48) | KDM4EF2F10F7F3 | |
| SCHEMBL7665736 | 0.73 | F3 (0.51) | KDM4EF2F10F7F3 | |
| SCHEMBL6781623 | 0.69 | ERN1 (0.67) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL7656288 | 0.67 | F3 (0.61) | KDM4EF2F10F7F3 | |
| SCHEMBL8889247 | 0.66 | KDM4E (0.83) | KDM4EMAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL3132145 | 0.66 | TDP1 (0.64) | KDM4ESMPD1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6781294 | 0.65 | HTT (0.59) | KDM4EMAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL14149879 | 0.65 | ESR1 (0.62) | KDM4EALDH1A1MAPK1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709646-B2 | Tetrahydroquinoline derivatives useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-05-04 | — | — | US | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |