Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | BCR | P11274 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348341 | 0.92 | MAPT (0.61) | MAPTPIK3CGCAMKK2MEN1NPC1 | |
| SCHEMBL3015105 | 0.86 | CDK5 (0.60) | CDK5PIK3CGCAMKK2ABL1BCR | |
| SCHEMBL8350467 | 0.85 | MAPT (0.51) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL5465150 | 0.81 | HDAC1 (0.58) | MAPTPIK3CGCAMKK2NPC1RAB9A | |
| SCHEMBL4003528 | 0.80 | ABL1 (0.58) | CDK5MAPTPIK3CGCAMKK2MEN1 | |
| SCHEMBL4901211 | 0.79 | CDK5 (0.75) | CDK5PIK3CGMEN1NPC1RAB9A | |
| SCHEMBL14348340 | 0.78 | MAPT (0.60) | MAPTPIK3CGCAMKK2MEN1NPC1 | |
| SCHEMBL12801118 | 0.78 | CDK5 (0.73) | CDK5PIK3CGMEN1NPC1RAB9A | |
| SCHEMBL8352374 | 0.77 | MAPT (0.57) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL2938991 | 0.76 | JAK2 (0.56) | PIK3CGCAMKK2PIK3CAPIK3CBMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |