Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.55 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353979 | 0.92 | CDK5 (0.58) | MAPTPIK3CGCAMKK2L3MBTL1KDM4E | |
| SCHEMBL5465150 | 0.84 | HDAC1 (0.58) | MAPTPIK3CGCAMKK2SMN1; SMN2GAA | |
| SCHEMBL8352374 | 0.83 | MAPT (0.57) | MAPTL3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL14348340 | 0.83 | MAPT (0.60) | MAPTPIK3CGCAMKK2L3MBTL1KDM4E | |
| SCHEMBL14253984 | 0.79 | CAMK2D (0.61) | PIK3CGCAMKK2PRKCAMAPK8JAK2 | |
| SCHEMBL14088787 | 0.78 | JAK2 (0.59) | PIK3CGCAMKK2PRKCAJAK2JAK3 | |
| SCHEMBL14253980 | 0.78 | CAMK2D (0.57) | PIK3CGCAMKK2PRKCAMAPK8JAK2 | |
| SCHEMBL5467323 | 0.78 | GAA (0.60) | MAPTPIK3CGKDM4EALDH1A1HPGD | |
| SCHEMBL14253972 | 0.77 | CAMKK2 (0.61) | PIK3CGCAMKK2PRKCAMAPK8JAK2 | |
| SCHEMBL2938991 | 0.77 | JAK2 (0.56) | PIK3CGCAMKK2MAPK8JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |