SCHEMBL8354012

SCHEMBL8354012

CC(C)OC(=O)OCOC(=O)[C@H]1[C@@H]2CC[C@@](N)(C(=O)OCOC(=O)OC(C)C)[C@@H]21

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC1A2 P43004 1/20 0.42
SLC1A1 P43005 1/20 0.42
GRM8 O00222 1/20 0.38
GRM6 O15303 1/20 0.38
GRM2 Q14416 1/20 0.38
GRM3 Q14832 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6701165 0.90 GRM8 (0.50) SLC1A2SLC1A1GRM8GRM6GRM2
SCHEMBL6703430 0.90 SLC1A2 (0.55) SLC1A2SLC1A1GRM8GRM6GRM2
Hydrochloric Acid SCHEMBL6703425 0.89 SLC1A2 (0.53) SLC1A2SLC1A1GRM8GRM6GRM2
SCHEMBL8354226 0.89 SLC1A2 (0.44) SLC1A2SLC1A1GRM8GRM6GRM2
Hydrochloric Acid SCHEMBL6702822 0.87 SLC1A2 (0.38) SLC1A2SLC1A1GRM8GRM6GRM2
SCHEMBL8358720 0.86 SLC1A2 (0.44) SLC1A2SLC1A1GRM8GRM6GRM2
SCHEMBL8354778 0.80 SLC1A2 (0.43) SLC1A2SLC1A1GRM8GRM6GRM2
SCHEMBL6704928 0.79 GRM2 (0.54) SLC1A2SLC1A1GRM8GRM6GRM2
SCHEMBL8358688 0.78 SLC1A2 (0.40) SLC1A2SLC1A1GRM8GRM6GRM2
SCHEMBL5690924 0.76 SLC1A2 (0.46) SLC1A2SLC1A1GRM8GRM6GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003045898-A1 PRODRUGS OF EXCITATORY AMINO ACIDS ELI LILLY AND COMPANY (US) 2003-06-05 WO disclosed