Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358764 | 1.00 | ROCK2 (0.56) | ROCK2ROCK1MAPK14HRH3POLB | |
| SCHEMBL5409738 | 0.96 | ROCK2 (0.56) | ROCK2ROCK1MAPK14HRH3POLB | |
| SCHEMBL5406977 | 0.95 | ROCK2 (0.56) | ROCK2ROCK1MAPK14HRH3POLB | |
| SCHEMBL5415771 | 0.94 | ROCK2 (0.56) | ROCK2ROCK1MAPK14HRH3CCNC | |
| SCHEMBL5413131 | 0.94 | ROCK2 (0.56) | ROCK2ROCK1MAPK14HRH3CCNC | |
| SCHEMBL5423920 | 0.93 | ROCK2 (0.56) | ROCK2ROCK1MAPK14HRH3CCNC | |
| SCHEMBL8354510 | 0.92 | HRH3 (0.48) | ROCK2ROCK1MAPK14HRH3MAOB | |
| SCHEMBL8357104 | 0.92 | HRH3 (0.48) | ROCK2ROCK1MAPK14HRH3MAOB | |
| SCHEMBL5417370 | 0.90 | ROCK2 (0.65) | ROCK2ROCK1MAPK14HRH3POLB | |
| SCHEMBL5415065 | 0.88 | ROCK2 (0.65) | ROCK2ROCK1MAPK14HRH3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305675-A1 | Indazoles, Benzothiazoles, and Benzoisothiazoles, and preparation and uses thereof | Memory Pharmaceuticals Corporation (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2004029050-A1 | INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-04-08 | — | — | WO | disclosed |