SCHEMBL8354729

SCHEMBL8354729

CCCC[C@H](NC(=O)OC1C(=O)OC[C@]1(C)CC)C(=O)C(=O)N[C@H](C)c1ccccc1

nearest known ligand 0.84

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CTSK P43235 20/20 0.84
CTSV O60911 5/20 0.84
CTSL P07711 5/20 0.84
CTSS P25774 5/20 0.84
CTSB P07858 2/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6197793 0.91 CTSK (1.00) CTSKCTSVCTSLCTSSCTSB
SCHEMBL14104869 0.84 CTSK (0.60) CTSKCTSVCTSLCTSSCTSB
SCHEMBL8354383 0.81 CTSK (1.00) CTSKCTSVCTSLCTSSCTSB
SCHEMBL8354386 0.81 CTSK (1.00) CTSKCTSVCTSLCTSSCTSB
SCHEMBL8356928 0.80 CTSK (0.79) CTSKCTSVCTSLCTSSCTSB
SCHEMBL4818454 0.80 CTSK (0.79) CTSKCTSVCTSLCTSSCTSB
SCHEMBL4818447 0.80 CTSK (0.79) CTSKCTSVCTSLCTSSCTSB
SCHEMBL4817812 0.80 CTSK (0.71) CTSKCTSVCTSLCTSSCTSB
SCHEMBL4817827 0.80 CTSK (0.71) CTSKCTSVCTSLCTSSCTSB
SCHEMBL6411425 0.77 CTSK (1.00) CTSKCTSVCTSLCTSSCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7402606-B2 Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss SMITHKLINE BEECHAM CORPORATION (US) 2008-07-22 US disclosed
US-7402606-B2 Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss SMITHKLINE BEECHAM CORPORATION (US) 2008-07-22 US disclosed
WO-2003086385-A1 DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS SMITHKLINE BEECHAM CORPORATION (US) 2003-10-23 WO disclosed