Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31732385 | 1.00 | POLB (0.62) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL28586117 | 0.92 | POLB (0.54) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL26934006 | 0.85 | POLB (0.56) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL8355960 | 0.85 | POLB (0.56) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL29122077 | 0.83 | POLB (0.59) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL26947842 | 0.81 | POLB (0.52) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL6479282 | 0.81 | POLB (0.64) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL28284859 | 0.79 | POLB (0.58) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL6489161 | 0.79 | POLB (0.61) | POLBCYP1A2ALPLCYP2C9CYP2C19 | |
| SCHEMBL28581193 | 0.78 | POLB (0.52) | POLBCYP1A2ALPLCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4536667-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | Institut National de la Santé et de la Recherche Médicale (FR) | 2025-04-16 | — | — | EP | disclosed |
| WO-2023237580-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023237580-A1 | TRICYCLIC SPIROLACTAM COMPOUNDS WITH ANTIMYCOBACTERIAL ACTIVITY | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2023-12-14 | — | — | WO | disclosed |
| US-7598242-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2009-10-06 | — | — | US | disclosed |
| US-7598242-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2009-10-06 | — | — | US | disclosed |
| WO-2003053915-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |