Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31732385 | 0.85 | POLB (0.62) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL8355458 | 0.85 | POLB (0.62) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL26934006 | 0.83 | POLB (0.56) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL26947842 | 0.80 | POLB (0.52) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL28586117 | 0.78 | POLB (0.54) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL6489161 | 0.77 | POLB (0.61) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL28581193 | 0.76 | POLB (0.52) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL6489166 | 0.76 | POLB (0.59) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL6479282 | 0.76 | POLB (0.64) | POLBALDH1A1HPGDHTTCYP1A2 | |
| SCHEMBL28284859 | 0.75 | POLB (0.58) | POLBALDH1A1HPGDHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598242-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2009-10-06 | — | — | US | disclosed |
| US-7598242-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2009-10-06 | — | — | US | disclosed |
| WO-2003053915-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |