Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351497 | 0.97 | SLC6A2 (0.46) | POLBSLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL8352799 | 0.94 | POLB (0.47) | POLBOPRM1RECQLSMN1; SMN2TSHR | |
| SCHEMBL8353270 | 0.88 | HRH3 (0.50) | SLC6A2SLC6A4SLC6A3SMN1; SMN2LMNA | |
| SCHEMBL5644974 | 0.85 | SLC6A2 (0.43) | POLBSLC6A2SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL8353945 | 0.85 | SLC6A2 (0.58) | POLBSLC6A2SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL8351057 | 0.84 | HRH3 (0.50) | SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL8352947 | 0.83 | HRH3 (0.51) | OPRM1SMN1; SMN2LMNA | |
| SCHEMBL8354149 | 0.82 | HRH3 (0.38) | POLBOPRM1LMNAGAAHPGD | |
| SCHEMBL8351474 | 0.82 | SLC6A2 (0.62) | POLBSLC6A2SLC6A4SLC6A3SMN1; SMN2 | |
| SCHEMBL8351051 | 0.80 | KCNA3 (0.38) | TACR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312214-B2 | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2003099276-A1 | 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-04 | — | — | WO | disclosed |