Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13609513 | 0.80 | TSHR (0.41) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL8358094 | 0.76 | SMN1; SMN2 (0.82) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL999419 | 0.75 | ALDH1A1 (0.41) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL998860 | 0.74 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL8509234 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KMT2A | |
| SCHEMBL9072430 | 0.73 | ALDH1A1 (0.40) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL8350499 | 0.73 | GAA (0.77) | POLBSMN1; SMN2GAAALDH1A1MAPK1 | |
| SCHEMBL27760073 | 0.72 | ALDH1A1 (0.51) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL998451 | 0.72 | ALDH1A1 (0.39) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL11223273 | 0.71 | MAPT (0.63) | MAPTGAAALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |