Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | FHIT | P49789 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262436 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1POLBMAPK1GAA | |
| SCHEMBL999513 | 0.70 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1POLBMAPK1GAA | |
| SCHEMBL25429739 | 0.68 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1TRPA1POLBMAPK1 | |
| SCHEMBL999179 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBMAPK1GAA | |
| SCHEMBL29093433 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBMAPK1GAA | |
| SCHEMBL998860 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBMAPK1GAA | |
| SCHEMBL25430779 | 0.67 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TRPA1POLBMAPK1 | |
| SCHEMBL2720641 | 0.67 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1GAAMAPTHPGD | |
| SCHEMBL13799644 | 0.66 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1POLBMAPK1GAA | |
| SCHEMBL15820523 | 0.66 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TRPA1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |