Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.48 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354520 | 0.79 | MEN1 (0.54) | MEN1KMT2AMCL1BCL2L1BAK1 | |
| SCHEMBL8359140 | 0.76 | MEN1 (0.51) | MEN1KMT2AMCL1BCL2L1BAK1 | |
| SCHEMBL5915295 | 0.76 | MEN1 (1.00) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL5915297 | 0.73 | KMT2A (0.83) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL12463056 | 0.73 | MCL1 (0.47) | MEN1KMT2AMCL1BCL2L1BAK1 | |
| SCHEMBL18392418 | 0.72 | MCL1 (0.85) | MEN1KMT2AMCL1BCL2L1BAK1 | |
| SCHEMBL5253603 | 0.72 | MMP8 (0.53) | MEN1KMT2AMCL1NPSR1ALDH1A1 | |
| SCHEMBL14002947 | 0.72 | MEN1 (0.49) | MEN1KMT2AMCL1KCNN4KCNA3 | |
| SCHEMBL2152553 | 0.72 | MCL1 (0.45) | MEN1KMT2AMCL1BCL2L1BAK1 | |
| SCHEMBL5252095 | 0.71 | NPSR1 (0.50) | MEN1KMT2ANPSR1ALDH1A1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492765-B1 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORP (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2003014075-A2 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |