Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.67 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353831 | 0.96 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL8350055 | 0.88 | CASP2 (0.72) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL6229213 | 0.87 | SMN1; SMN2 (0.82) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL10576093 | 0.85 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL14202814 | 0.85 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL27022345 | 0.85 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL29500248 | 0.84 | CASP2 (0.77) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL8353964 | 0.84 | CASP2 (0.77) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL9332424 | 0.84 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL15376318 | 0.83 | MAPT (0.78) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |