SCHEMBL8358142

SCHEMBL8358142

COc1cccc2sc(Cc3ccc(Cl)cc3)nc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.62
TDP1 Q9NUW8 2/20 0.51
CYP3A4 P08684 1/20 0.51
MAPT P10636 7/20 0.48
KDM4E B2RXH2 2/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
GAA P10253 1/20 0.48
RAB9A P51151 4/20 0.44
NPC1 O15118 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
TP53 P04637 2/20 0.44
HPGD P15428 1/20 0.44
NFKB1 P19838 1/20 0.44
NFKB2 Q00653 1/20 0.44
RELA Q04206 1/20 0.44
DYRK1A Q13627 1/20 0.44
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TSHR P16473 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8358531 0.80 ALDH1A1 (0.48) ALDH1A1TDP1MAPTKDM4EMEN1
SCHEMBL8361492 0.79 PDPK1 (0.47) ALDH1A1MAPTKDM4EMEN1KMT2A
SCHEMBL6173275 0.78 ALDH1A1 (0.61) ALDH1A1TDP1CYP3A4MAPTKDM4E
SCHEMBL2000543 0.78 ALDH1A1 (1.00) ALDH1A1TDP1CYP3A4MAPTKDM4E
SCHEMBL13326478 0.77 ALDH1A1 (0.59) ALDH1A1TDP1CYP3A4MAPTKDM4E
SCHEMBL22257088 0.77 ALDH1A1 (0.59) ALDH1A1TDP1CYP3A4MAPTKDM4E
SCHEMBL3244190 0.77 TDP1 (0.64) ALDH1A1TDP1CYP3A4MAPTKDM4E
SCHEMBL30785981 0.77 ALDH1A1 (0.59) ALDH1A1TDP1CYP3A4MAPTKDM4E
SCHEMBL22230648 0.75 ALDH1A1 (0.50) ALDH1A1TDP1CYP3A4MAPTKDM4E
SCHEMBL28984550 0.72 PTGS1 (0.57) ALDH1A1TDP1CYP3A4MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5919807-A ANTICHOLESTEROL AGENTS DR. KARL THOMAE GMBH (DE) 1999-07-06 US disclosed
EP-0824529-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-02-25 EP disclosed
WO-1996035681-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM DR. KARL THOMAE GMBH (DE) 1996-11-14 WO disclosed