SCHEMBL8358374

SCHEMBL8358374

Cc1ccc(CNC(=O)c2cc(C(=O)NCc3ccc(C)cc3)ncn2)cc1

nearest known ligand 0.71

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 6/20 0.71
L3MBTL1 Q9Y468 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.62
POLB P06746 2/20 0.57
KMT2A Q03164 2/20 0.56
MMP10 P09238 1/20 0.52
MMP9 P14780 1/20 0.52
MMP8 P22894 1/20 0.52
ALDH1A1 P00352 3/20 0.51
HPGD P15428 3/20 0.51
MEN1 O00255 1/20 0.51
KDM4E B2RXH2 3/20 0.50
MAPT P10636 1/20 0.50
THRB P10828 1/20 0.50
HTT P42858 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17132761 0.85 MMP13 (0.75) MMP13L3MBTL1SMN1; SMN2POLBKMT2A
SCHEMBL8358406 0.84 MMP13 (0.71) MMP13SMN1; SMN2KMT2AALDH1A1HPGD
SCHEMBL8358839 0.84 MMP13 (0.71) MMP13L3MBTL1SMN1; SMN2POLBKMT2A
SCHEMBL8358840 0.83 MMP13 (1.00) MMP13POLBMMP10MMP9MMP8
SCHEMBL7630281 0.83 MMP13 (0.66) MMP13L3MBTL1SMN1; SMN2POLBKMT2A
SCHEMBL8358440 0.83 MMP13 (0.66) MMP13L3MBTL1SMN1; SMN2KMT2AMMP10
SCHEMBL17132755 0.83 MMP13 (0.76) MMP13L3MBTL1SMN1; SMN2POLBKMT2A
SCHEMBL17132756 0.82 MMP13 (0.79) MMP13L3MBTL1SMN1; SMN2POLBMMP10
SCHEMBL14448481 0.82 MMP13 (0.55) MMP13L3MBTL1SMN1; SMN2POLBKMT2A
SCHEMBL5212608 0.82 SMN1; SMN2 (0.64) MMP13L3MBTL1SMN1; SMN2POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1455790-B1 USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION SANOFI AVENTIS DEUTSCHLAND (DE) 2008-03-26 EP disclosed
WO-2003049738-A1 USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-06-19 WO disclosed