Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | SLC6A12 | P48065 | 3/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | OAT | P04181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL2389239 | 0.89 | FFAR3 (0.37) | GABRR1SLC6A12SLC6A11SLC6A13PEPD | |
| Bicarbonate SCHEMBL578685 | 0.84 | — | — | |
| SCHEMBL8236493 | 0.84 | — | — | |
| SCHEMBL1080038 | 0.84 | — | — | |
| SCHEMBL1224698 | 0.84 | — | — | |
| SCHEMBL1353564 | 0.84 | — | — | |
| SCHEMBL19774666 | 0.84 | — | — | |
| SCHEMBL28130238 | 0.84 | THRB (0.38) | KDM1A | |
| SCHEMBL63567 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL7211625 | 0.83 | CHRM3 (0.36) | GABRR1OAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776933-B1 | Polybutene-1 resin composition and a method of accelerating the crystal transformation | NEW JAPAN CHEM CO LTD (JP) | 1999-08-04 | — | — | EP | claimed |