Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 2/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.38 |
| ▸ | PPM1D | O15297 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359281 | 1.00 | CDC25A (0.38) | CDC25ACDC25BPPM1DJAK2JAK1 | |
| SCHEMBL8359283 | 1.00 | CDC25A (0.38) | CDC25ACDC25BPPM1DJAK2JAK1 | |
| SCHEMBL7145028 | 0.86 | CDC25A (0.40) | CDC25ACDC25BPPM1DGPBAR1 | |
| SCHEMBL7145023 | 0.86 | CDC25A (0.40) | CDC25ACDC25BPPM1DGPBAR1 | |
| SCHEMBL7145089 | 0.85 | CDC25A (0.42) | CDC25ACDC25BPPM1DGPBAR1 | |
| SCHEMBL8201371 | 0.85 | CDC25A (0.42) | CDC25ACDC25BPPM1DGPBAR1 | |
| SCHEMBL7145024 | 0.85 | CDC25A (0.42) | CDC25ACDC25BPPM1DGPBAR1 | |
| SCHEMBL8207424 | 0.84 | PPM1D (0.34) | CDC25ACDC25BPPM1D | |
| SCHEMBL8207420 | 0.84 | PPM1D (0.34) | CDC25ACDC25BPPM1D | |
| SCHEMBL8098457 | 0.82 | CDC25A (0.39) | CDC25ACDC25BPPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919986-A | SKIN DISORDERS; OSTEOPOROSIS; KIDNEY DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. (US) | 1999-07-06 | — | — | US | disclosed |