Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361047 | 1.00 | PTGS2 (0.72) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8356529 | 0.95 | PTGS2 (0.81) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8353891 | 0.95 | PTGS2 (0.81) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8354817 | 0.95 | PTGS2 (0.68) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8354812 | 0.95 | PTGS2 (0.68) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8358998 | 0.95 | PTGS2 (0.65) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8360475 | 0.95 | PTGS2 (0.65) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8360278 | 0.88 | PTGS2 (0.69) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8354849 | 0.88 | PTGS2 (0.69) | PTGS2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL8360567 | 0.88 | PTGS2 (0.69) | PTGS2HDAC3HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |