Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | PHGDH | O43175 | 3/20 | 0.51 |
| ▸ | MPL | P40238 | 2/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | USP8 | P40818 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727086 | 0.86 | NPSR1 (0.59) | KDM1AMPLUSP2USP8MEN1 | |
| SCHEMBL727095 | 0.84 | KDM1A (0.59) | KDM1AMPLUSP2USP8MEN1 | |
| SCHEMBL16798990 | 0.84 | MEN1 (0.66) | KDM1AMPLUSP2USP8MEN1 | |
| SCHEMBL8357471 | 0.83 | MEN1 (0.63) | MAPTKDM1AMPLMEN1KMT2A | |
| SCHEMBL8355149 | 0.80 | MEN1 (0.54) | MAPTKDM1AMPLMEN1KMT2A | |
| SCHEMBL8110979 | 0.79 | KDM1A (0.61) | MAPTKDM1AMPLUSP2USP8 | |
| SCHEMBL15689027 | 0.77 | MAPT (0.70) | MAPTKDM1APHGDHUSP2USP8 | |
| SCHEMBL15698846 | 0.74 | PHGDH (0.63) | MAPTKDM1APHGDHUSP2USP8 | |
| SCHEMBL2762864 | 0.74 | MAPT (0.77) | MAPTKDM1APHGDHMEN1KMT2A | |
| SCHEMBL15496614 | 0.73 | IDO1 (0.75) | MAPTKDM1AIDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | disclosed |