Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | KMO | O15229 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.53 |
| ▸ | KDM1A | O60341 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | MPL | P40238 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357471 | 0.88 | MEN1 (0.63) | MEN1KMT2ASCN9AKDM1AALDH1A1 | |
| SCHEMBL727086 | 0.85 | NPSR1 (0.59) | MEN1KMT2AKDM1AMPL | |
| SCHEMBL727095 | 0.83 | KDM1A (0.59) | MEN1KMT2ASCN9AKDM1AMPL | |
| SCHEMBL16798990 | 0.83 | MEN1 (0.66) | MEN1KMT2AKDM1AMPL | |
| SCHEMBL8360832 | 0.80 | MAPT (0.64) | MEN1KMT2AKDM1AALDH1A1MAPT | |
| SCHEMBL727070 | 0.78 | MPL (0.49) | MEN1KMT2AMAPK1ALOX15ALDH1A1 | |
| SCHEMBL8110979 | 0.78 | KDM1A (0.61) | MEN1KMT2AKDM1AMAPTMPL | |
| SCHEMBL8356755 | 0.76 | KDM1A (0.67) | MEN1KMT2AMAPK1KMOSCN9A | |
| SCHEMBL8360672 | 0.73 | KMO (0.69) | MEN1KMT2AMAPK1KMOKDM1A | |
| SCHEMBL8360649 | 0.71 | KDM1A (0.66) | MEN1KMT2AMAPK1ALOX15KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | claimed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | claimed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | claimed |
| WO-2015082900-A1 | A CELLULAR DRUG SCREENING METHOD USING FACS AND LC-MS. | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2015-06-11 | — | — | WO | disclosed |
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | disclosed |