Tetrahydrothiophene

Tetrahydrothiophene

SCHEMBL8360837

C1CCSC1.Cc1ccc(C)nc1

nearest known ligand 0.43

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.43
CCR1 P32246 1/20 0.43
CCR5 P51681 1/20 0.43
CCR8 P51685 1/20 0.43
NOS3 P29474 1/20 0.40
NOS2 P35228 1/20 0.40
HPGDS O60760 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2A6 P11509 1/20 0.35
LMNA P02545 1/20 0.34
ADRA2A P08913 4/20 0.33
ADRA2B P18089 4/20 0.33
ADRA2C P18825 4/20 0.33
RAB9A P51151 3/20 0.33
PLAU P00749 1/20 0.33
MAPT P10636 1/20 0.33
HDAC1 Q13547 1/20 0.32
METAP2 P50579 1/20 0.32
CHRNB1 P11230 1/20 0.31
CHRNB2 P17787 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31030 0.82
SCHEMBL31218494 0.82
SCHEMBL10765894 0.82 HDAC6 (0.60) HDAC6CCR1CCR5CCR8NOS3
Bromide SCHEMBL30803907 0.79
Hydrochloric Acid SCHEMBL7013377 0.79
Hydrochloric Acid SCHEMBL31187339 0.79
P-Xylene SCHEMBL4462544 0.77 ACHE (0.50) LMNAMAPT
P-Xylene SCHEMBL7998231 0.74 ACHE (0.47) LMNAMAPT
P-Xylene SCHEMBL1272647 0.74 ACHE (0.47) LMNARAB9AMAPTNPC1
Perchlorate SCHEMBL8011205 0.70 HDAC6 (0.46) HDAC6CCR1CCR5CCR8NOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817430-A POLYARYLENEVINYLENE POLYMER XEROX CORPORATION (US) 1998-10-06 US claimed
US-5876865-A POLYARYLENEVINYLENE RESIN XEROX CORPORATION (US) 1999-03-02 US disclosed
US-5817430-A POLYARYLENEVINYLENE POLYMER XEROX CORPORATION (US) 1998-10-06 US disclosed