Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 6/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361504 | 0.99 | NPC1 (0.55) | NPC1TSHRRAB9AMAPTL3MBTL1 | |
| SCHEMBL8359521 | 0.83 | LTA4H (0.60) | NPC1TSHRRAB9ALTA4HAURKB | |
| SCHEMBL8357943 | 0.82 | MAPT (0.60) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL8362101 | 0.82 | LTA4H (0.61) | NPC1TSHRRAB9ALTA4HAURKB | |
| SCHEMBL8358459 | 0.81 | MAPT (0.58) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL8361623 | 0.80 | MAPT (0.80) | NPC1TSHRRAB9AMAPTL3MBTL1 | |
| SCHEMBL8355863 | 0.80 | MAPT (0.60) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL8359745 | 0.80 | MAPT (0.60) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL8355890 | 0.78 | MAPT (0.61) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL8361935 | 0.77 | MAPT (0.60) | NPC1RAB9AMAPTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919807-A | ANTICHOLESTEROL AGENTS | DR. KARL THOMAE GMBH (DE) | 1999-07-06 | — | — | US | disclosed |
| EP-0824529-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035681-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-11-14 | — | — | WO | disclosed |