Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29523504 | 0.89 | HDAC1 (0.52) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL164105 | 0.89 | HDAC1 (0.52) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL27947682 | 0.88 | NAMPT (0.48) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL16296315 | 0.86 | NAMPT (0.48) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL13188545 | 0.85 | NAMPT (0.47) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL19669455 | 0.85 | NAMPT (0.47) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL30684531 | 0.85 | P4HTM (0.48) | HDAC1NAMPTGRIN2BCYP17A1GSK3B | |
| SCHEMBL30684527 | 0.85 | P4HTM (0.48) | HDAC1NAMPTGRIN2BCYP17A1GSK3B | |
| SCHEMBL15354526 | 0.85 | NAMPT (0.50) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL540536 | 0.85 | NAMPT (0.50) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465736-B2 | Azole methylidene cyanide derivatives and their use as protein kinase modulators | LABORATOIRES SERONO S.A. (CH) | 2008-12-16 | — | — | US | disclosed |
| US-7465736-B2 | Azole methylidene cyanide derivatives and their use as protein kinase modulators | LABORATOIRES SERONO S.A. (CH) | 2008-12-16 | — | — | US | disclosed |
| US-20070123530-A1 | Azole methylidene cyanide derivatives and their use as protein kinase modulators | MERCK SERONO SA (CH) | 2007-05-31 | — | — | US | disclosed |
| US-20070123530-A1 | Azole methylidene cyanide derivatives and their use as protein kinase modulators | MERCK SERONO SA (CH) | 2007-05-31 | — | — | US | disclosed |
| WO-2003106455-A1 | AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123530-A1 | Azole methylidene cyanide derivatives and their use as protein kinase modulators | PRKACA, CSNK1A1, PRKACG | HDAC1 1868/4885NAMPT 834/4885GRIN2B 3436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.