Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.73 |
| ▸ | AURKA | O14965 | 8/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363548 | 0.85 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL3320599 | 0.82 | EGFR (0.76) | EGFRERBB2AURKBCSF1R | |
| SCHEMBL8361665 | 0.80 | EGFR (0.87) | EGFRERBB2AURKB | |
| SCHEMBL8537365 | 0.79 | EGFR (0.63) | EGFRERBB2AURKAAURKBCSF1R | |
| SCHEMBL8360741 | 0.79 | EGFR (0.90) | EGFRERBB2 | |
| SCHEMBL8368189 | 0.78 | EGFR (0.87) | EGFRERBB2AURKB | |
| SCHEMBL8364953 | 0.77 | AURKA (0.55) | EGFRERBB2AURKAAURKBBRAF | |
| SCHEMBL8364217 | 0.76 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL8367271 | 0.75 | EGFR (0.82) | EGFRERBB2AURKB | |
| SCHEMBL12694408 | 0.74 | EGFR (0.68) | EGFRERBB2AURKAAURKBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |