SCHEMBL8364276

SCHEMBL8364276

CNC(=O)c1ccc(CCC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7747432 0.91 BDKRB2 (0.72) BDKRB2
SCHEMBL8365936 0.89 BDKRB2 (0.63) BDKRB2
SCHEMBL8364355 0.89 BDKRB2 (0.75) BDKRB2
SCHEMBL8366005 0.89 BDKRB2 (0.74) BDKRB2
SCHEMBL8365931 0.88 BDKRB2 (0.62) BDKRB2
SCHEMBL8361860 0.88 BDKRB2 (0.77) BDKRB2
SCHEMBL7748487 0.87 BDKRB2 (0.70) BDKRB2
SCHEMBL8364338 0.85 BDKRB2 (0.74) BDKRB2
SCHEMBL7743043 0.85 BDKRB2 (1.00) BDKRB2
SCHEMBL7743041 0.85 BDKRB2 (1.00) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed