SCHEMBL8364317

SCHEMBL8364317

Cc1cc(C)c2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)C=Cc4ccc(C=Cc5ccccn5)nc4)c3C)c2n1

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8364316 1.00 BDKRB2 (0.66) BDKRB2
SCHEMBL8804358 0.93 BDKRB2 (0.68) BDKRB2
SCHEMBL8804363 0.93 BDKRB2 (0.68) BDKRB2
SCHEMBL8366015 0.92 BDKRB2 (0.63) BDKRB2
SCHEMBL8366019 0.92 BDKRB2 (0.63) BDKRB2
SCHEMBL8366121 0.89 BDKRB2 (0.72) BDKRB2
SCHEMBL8516401 0.89 BDKRB2 (0.67) BDKRB2
SCHEMBL8366117 0.89 BDKRB2 (0.72) BDKRB2
SCHEMBL8516403 0.89 BDKRB2 (0.67) BDKRB2
SCHEMBL8364853 0.88 BDKRB2 (0.67) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed