Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.60 |
| ▸ | AURKA | O14965 | 5/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364112 | 0.95 | EGFR (0.62) | EGFRERBB2AURKAAURKB | |
| SCHEMBL8364953 | 0.93 | AURKA (0.55) | EGFRERBB2AURKAAURKBKDR | |
| SCHEMBL8363483 | 0.87 | EGFR (0.49) | EGFRERBB2AURKAAURKBKDR | |
| SCHEMBL8367193 | 0.87 | EGFR (0.61) | EGFRERBB2AURKAAURKB | |
| SCHEMBL8367387 | 0.86 | EGFR (0.50) | EGFRERBB2 | |
| SCHEMBL8516124 | 0.86 | EGFR (0.49) | EGFRERBB2AURKAAURKBKDR | |
| SCHEMBL8363554 | 0.84 | EGFR (0.47) | EGFRERBB2AURKAAURKBKDR | |
| SCHEMBL8367792 | 0.84 | EGFR (0.57) | EGFRERBB2KDR | |
| SCHEMBL8541789 | 0.84 | EGFR (0.47) | EGFRERBB2AURKAAURKBKDR | |
| SCHEMBL8367320 | 0.84 | EGFR (0.54) | EGFRERBB2AURKAAURKBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |