Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8367792 | 0.95 | EGFR (0.57) | EGFRERBB2BRAFALDH1A1HSD17B10 | |
| SCHEMBL8367320 | 0.94 | EGFR (0.54) | EGFRERBB2BRAFHSD17B10 | |
| SCHEMBL8367388 | 0.89 | EGFR (0.53) | EGFRERBB2SRC | |
| SCHEMBL8364100 | 0.88 | CNR1 (0.51) | EGFRERBB2BRAFUSP2CYP1A2 | |
| SCHEMBL8516124 | 0.88 | EGFR (0.49) | EGFRERBB2BRAFUSP2CYP1A2 | |
| SCHEMBL8364442 | 0.86 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL8363554 | 0.86 | EGFR (0.47) | EGFRERBB2BRAFHSD17B10 | |
| SCHEMBL8541789 | 0.85 | EGFR (0.47) | EGFRERBB2BRAFHSD17B10 | |
| SCHEMBL8364112 | 0.84 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL8366024 | 0.84 | EGFR (0.59) | EGFRERBB2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |