SCHEMBL8364488

SCHEMBL8364488

Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccc(C(=O)NCc5ccncc5)cc4)c3Cl)c2n1

nearest known ligand 0.73

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7748521 0.93 BDKRB2 (0.73) BDKRB2
SCHEMBL8367321 0.93 BDKRB2 (0.83) BDKRB2
Hydrochloric Acid SCHEMBL7747245 0.93 BDKRB2 (0.73) BDKRB2
SCHEMBL7746482 0.91 BDKRB2 (0.76) BDKRB2
SCHEMBL7828954 0.90 BDKRB2 (0.69) BDKRB2
Hydrochloric Acid SCHEMBL7747344 0.90 BDKRB2 (0.77) BDKRB2
Hydrochloric Acid SCHEMBL7743052 0.90 BDKRB2 (0.69) BDKRB2
SCHEMBL7742820 0.89 BDKRB2 (0.84) BDKRB2
SCHEMBL7742816 0.89 BDKRB2 (0.84) BDKRB2
SCHEMBL7747123 0.89 BDKRB2 (0.75) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed