SCHEMBL8364495

SCHEMBL8364495

CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8364496 1.00 BDKRB2 (1.00) BDKRB2
SCHEMBL8803481 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8803486 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8367341 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8367342 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8361823 0.95 BDKRB2 (0.92) BDKRB2
SCHEMBL8361827 0.95 BDKRB2 (0.92) BDKRB2
SCHEMBL8364406 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8364404 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8361422 0.94 BDKRB2 (1.00) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed