Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010779 | 0.81 | AGTR1 (0.41) | AGTR1 | |
| SCHEMBL8362047 | 0.80 | CHEK1 (0.39) | AGTR1THRBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2775939 | 0.71 | AGTR1 (0.50) | AGTR1 | |
| SCHEMBL8359936 | 0.68 | AGTR1 (0.45) | AGTR1KDM4EALDH1A1HPGD | |
| SCHEMBL8363467 | 0.67 | AGTR1 (0.36) | AGTR1 | |
| SCHEMBL7014100 | 0.67 | AGTR1 (0.46) | AGTR1 | |
| SCHEMBL7009867 | 0.65 | AGTR1 (0.50) | AGTR1 | |
| SCHEMBL6609615 | 0.65 | NPC1 (0.47) | SMN1; SMN2TP53HPGDMAPTMEN1 | |
| SCHEMBL7016027 | 0.63 | AGTR1 (0.42) | AGTR1 | |
| SCHEMBL7014690 | 0.63 | AGTR1 (0.42) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883111-A | STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-16 | — | — | US | disclosed |