SCHEMBL8364629

SCHEMBL8364629

Cc1ccc(NS(=O)(=O)Cc2ccc(Cl)cc2)c(=O)n1CCC(=O)O

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F2 P00734 20/20 0.56
PRSS1 P07477 12/20 0.56
PRSS2 P07478 3/20 0.56
PRSS3 P35030 3/20 0.56
F10 P00742 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7737354 0.89 F2 (0.54) F2PRSS1PRSS2PRSS3F10
SCHEMBL6848994 0.86 F2 (0.55) F2PRSS1PRSS2PRSS3F10
SCHEMBL6849007 0.83 F2 (0.52) F2PRSS1PRSS2PRSS3F10
SCHEMBL6850663 0.80 F2 (0.64) F2PRSS1PRSS2PRSS3F10
SCHEMBL7315509 0.79 F2 (0.49) F2PRSS1PRSS2PRSS3
SCHEMBL4432108 0.78 F2 (0.77) F2PRSS1PRSS2PRSS3F10
SCHEMBL6846379 0.77 F2 (0.65) F2PRSS1PRSS2PRSS3F10
SCHEMBL5124074 0.76 F2 (0.75) F2PRSS1PRSS2PRSS3F10
SCHEMBL4427658 0.75 F2 (0.60) F2PRSS1PRSS2PRSS3F10
SCHEMBL8366434 0.74 F2 (0.74) F2PRSS1PRSS2PRSS3F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6777431-B2 ANTICOAGULANTS CORVAS INTERNATIONAL, INC. 2004-08-17 US disclosed