Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.78 |
| ▸ | MMP2 | P08253 | 6/20 | 0.78 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364812 | 0.91 | MMP13 (0.76) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL5898973 | 0.88 | MMP13 (1.00) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL5898969 | 0.88 | MMP13 (0.82) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL8364987 | 0.87 | MMP13 (0.78) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL8361681 | 0.85 | MMP13 (0.78) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL8363040 | 0.85 | MMP13 (0.75) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL5898962 | 0.84 | MMP13 (0.72) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL8364898 | 0.84 | MMP13 (0.72) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL8363743 | 0.83 | MMP13 (0.71) | MMP13MMP2FPR2PROKR1MEN1 | |
| SCHEMBL5898960 | 0.83 | MMP13 (1.00) | MMP13MMP2FPR2PROKR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007954-A2 | SULFONYL ARYL HYDROXAMATES AND THEIR USE AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-01-30 | — | — | WO | disclosed |